Drug Interactions: No specific drug interactions have been demonstrated. 2009 Apr. Ann Emerg Med. Current management of ethylene glycol poisoning. “Poisoning from ethylene glycol is usually accidental, or the result of an attempted suicide.” Because of its physical properties, testing for ethylene glycol requires special equipment and can only be performed at a handful of hospitals and laboratories. Ethylene glycol toxicity is a type of toxic leukoencephalopathy. Ethylene glycol, best known as a component of antifreeze, has been ingested both deliberately and accidentally, resulting in neurotoxicity and renal failure. Objective. 4-MP Treatment was performed 7 hours after EG ingestion. Carcinogenesis, Mutagenesis, Impairment of Fertility: Long term carcinogenicity studies, genetic toxicity studies and reproductive toxicity studies in animals have not been performed with Polyethylene Glycol 3350, USP Powder for Oral Solution. BACKGROUND: Ethylene glycol poisoning causes metabolic acidosis and renal failure and may cause death. Pregnancy: Category C. Drugs 61(7):979-88. Fomepizole is a new agent with a specific indication by the U.S. Food and Drug Administration for the treatment of ethylene glycol poisoning.4, 6, … Reproductive Toxicity. The standard treatment is inhibition of alcohol dehydrogenase with ethanol, given in intoxicating doses, and adjunctive hemodialysis. The purpose of the present case report was to demonstrate 4-MP efficiency in EG poisoning in a 4-year-old child. Inhalation effects of ethylene glycol with an average concentration in the air up to 140-200 mg / cc. J.J. Devlin, M. Schwartz, in Encyclopedia of Toxicology (Third Edition), 2014. Fomepizole for the treatment of ethylene glycol poisoning. Fomepizole for the treatment of pediatric ethylene and diethylene glycol, butoxyethanol, and methanol poisonings. Brent J. Below is a list of common medications used to treat or reduce the symptoms of ethylene glycol poisoning. Brent J, McMartin K, Phillips S, et al. The alcohol dehydrogenase inhibitor 4-methylpyrazole (4-MP) is a new antidote of ethylene glycol (EG) intoxication. Lepik KJ, Levy AR, Sobolev BG, Purssell RA, DeWitt CR, Erhardt GD. 1999. . Ethylene glycol polymers with large carbon chains may be reproductive toxins, but ethylene glycol itself exhibits no developmental toxicity or detrimental effects to reproductive health in humans. Brent J. 2010. 2001. Clin Toxicol 48(5):401-6. Cofactors for Ethylene Glycol and Methanol Poisoning In their 2009 annual report, the American Association of Poison Control Centers reported 91,973 exposures to toxic alcohols, resulting in over 30 deaths. Fomepizole is the generic drug name for the chemical 4-methylpyrazole (4-MP) now widely available in Europe and North America for the treatment of methanol and ethylene glycol poisoning. Amitava Dasgupta, Role of the Laboratory in Detecting Other Poisoning, Including Pesticides, Ethylene Glycol, and Methanol, Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring, 10.1002/9781118347867, (139-160), (2012). Nearly half of these deaths were due to ethylene glycol or methanol. Adverse drug events associated with the antidotes for methanol and ethylene glycol poisoning: a comparison of ethanol and fomepizole. Method and Results. 53(4):439-450.e10. Ra, DeWitt CR, Erhardt GD J, McMartin K, Phillips S, et al glycol EG. Glycol toxicity is a new antidote of ethylene glycol ethylene glycol poisoning drug of choice: a comparison of and... Cause death efficiency in EG poisoning in a 4-year-old child glycol or methanol a... Ethanol and fomepizole Interactions: No specific drug Interactions have been demonstrated Purssell RA DeWitt! J, McMartin K, Phillips S, et al for the treatment of ethylene! 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